Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic TreatmentReport as inadecuate




Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic Treatment - Download this document for free, or read online. Document in PDF available to download.

Disease Markers - Volume 25 2008, Issue 3, Pages 181-188



Department of Neurosciences, Hospital Germans Trias i Pujol, Departament de Medicina, Universitat Autònoma de Barcelona, Spain

Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clínico Universitario, Universidad de Santiago de Compostela, Spain

Unit of Bioestatistics, Hospital Doctor Josep Trueta, Girona, Spain

Department of Neurology, Hospital de la Princesa, Madrid, Spain

Department of Neurology, Hospital Doctor Josep Trueta, Girona, Spain

Department of Radiology, Hospital Germans Trias i Pujol, Departament de Medicina, Universitat Autònoma de Barcelona, Spain

Received 8 December 2008; Accepted 8 December 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and purpose: Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute stroke patients treated with i.v. t-PA.

Methods: Serum levels of ferritin as index of increased cellular iron stores, glutamate, interleukin-6, matrix metalloproteinase-9 and cellular fibronectin were determined in 134 patients treated with i.v. t-PA within 3 hours from stroke onset in blood samples obtained before t-PA treatment, at 24 and 72 hours.

Results: Serum ferritin levels before t-PA infusion correlated to glutamate r = 0.59, p < 0.001 and interleukin-6 r = 0.55,p <0.001 levels at baseline, and with glutamate r = 0.57,p <0.001, interleukin-6 r = 0.49,p <0.001, metalloproteinase-9r = 0.23, p = 0.007 and cellular fibronectin r = 0.27, p = 0.002 levels measured at 24 hours and glutamate r = 0.415,p < 0.001, interleukin-6 r = 0.359, p < 0.001 and metalloproteinase-9 r = 0.261, p = 0.004 at 72 hours. The associationbetween ferritin and glutamate levels remained after adjustment for confounding factors in generalized linear models.

Conclusions: Brain damage associated with increased iron stores in acute ischemic stroke patients treated with iv. tPA may be mediated by mechanisms linked to excitotoxic damage. The role of inflammation, blood brain barrier disruption and oxidative stress in this condition needs further research.





Author: Mónica Millán, Tomás Sobrino, Juan Francisco Arenillas, Manuel Rodríguez-Yáñez, María García, Florentino Nombela, Mar Cas

Source: https://www.hindawi.com/



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