The correlation between the bronchial hyperresponsiveness to methacholine and asthma like symptoms by GINA questionnaires for the diagnosis of asthmaReport as inadecuate




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BMC Pulmonary Medicine

, 14:161

Asthma and allergic disorders

Abstract

BackgroundIn epidemiological studies of asthma, questionnaires to differentiate asthmatics from non-asthmatics have proven to be cost-effective and convenient. The aim of this study was to analyze the association between hyperresponsiveness to methacholine and the validity of five items for the asthma like questionnaire recommended by the Global Initiative for Asthma GINA.

MethodsA total of 680 subjects who visited the pulmonology department with suspected symptoms of asthma were enrolled. All participants completed five items questionnaires and underwent methacholine bronchial provocation tests MBPT. The diagnostic value of the questionnaire was assessed through analysis of the sensitivity, specificity, and positive and negative predictive values.

ResultsMultivariate logistic regression analysis showed that questionnaires about wheezing, exercise induced dyspnea and pollution-induced dyspnea were useful for differentiating asthmatics from non-asthmatics adjusted odds ratio OR =2.0, 95% confidence interval CI 1.3-3.0; OR =2.3, 95% CI 1.5-3.5; OR =2.0, 95% CI 1.3-3.0 respectively. A total symptom score of higher than 1 was associated with the highest sensitivity 98.4% and lowest specificity 9.4%. In contrast, a total symptom score of more than 5 was associated with the highest specificity 91.9% and lowest sensitivity 18.5%

ConclusionsAlthough questionnaires are not a sufficiently accurate method for diagnosing asthma, properly selected questionnaire can be used as effective strategies in situations such as private clinics or large population based epidemiologic studies.

KeywordsQuestionnaire Bronchial hyper responsiveness Asthma like symptoms Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-161 contains supplementary material, which is available to authorized users.

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Author: So Yeon Lim - Young Joo Jo - Eun Mi Chun

Source: https://link.springer.com/







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