Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery: a retrospective studyReport as inadecuate




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BMC Anesthesiology

, 14:95

Critical care

Abstract

BackgroundProlonged storage of red blood cells RBCs leads to fundamental changes in both the RBCs and the storage media. We retrospectively evaluated the relationship between the RBC age and in-hospital and long-term postoperative outcomes in patients undergoing off-pump coronary artery bypass.

MethodsThe electronic medical records of 1,072 OPCAB patients were reviewed and information on the transfused RBCs and clinical data were collected. The effects of RBCs age mean age, oldest age of transfused RBCs, any RBCs older than 14 days on various in-hospital postoperative complications and long-term major adverse cardiovascular and cerebral events over a mean follow-up of 31 months were investigated. Correlations between RBCs age and duration of intubation, intensive care unit, or hospital stay, and base excess at the first postoperative morning were also analyzed.

ResultsAfter adjusting for confounders, there was no relationship between the RBCs age and in-hospital and long-term clinical outcomes except for postoperative wound complications. A significant linear trend was observed between the oldest age quartiles of transfused RBCs and the postoperative wound complications quartile 1 vs. 2, 3 and 4: OR, 8.92, 12.01 and 13.79, respectively; P for trend = 0.009. The oldest transfused RBCs showed significant relationships with a first postoperative day negative base excess P = 0.021, postoperative wound complications P = 0.001, and length of hospital stay P = 0.008.

ConclusionsIn patients undergoing off-pump coronary artery bypass, the oldest age of transfused RBCs were associated with a postoperative negative base excess, increased wound complications, and a longer hospital stay, but not with the other in-hospital or long-term outcomes.

KeywordsRBC storage age Old stored RBC Postoperative outcome Wound complication Cardiac surgery AbbreviationsRBCRed blood cell

OPCABOff-pump coronary artery bypass

MACCEMajor adverse cardiovascular and cerebral event

ICUIntensive care unit

CABGCoronary artery bypass grafting.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2253-14-95 contains supplementary material, which is available to authorized users.

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Author: Jeong Jin Min - Jun-Yeol Bae - Tae Kyong Kim - Deok Man Hong - Ho Young Hwang - Ki-Bong Kim - Kyou-Sup Han - Yunseok J

Source: https://link.springer.com/







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