Molecular Targets Related to Inflammation and Insulin Resistance and Potential InterventionsReport as inadecuate

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Journal of Biomedicine and BiotechnologyVolume 2012 2012, Article ID 379024, 16 pages

Review Article

Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, 01506-000 São Paulo, SP, Brazil

Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, Brazil

Institute of Biology, University State of Campinas, 13083-970 Campinas, SP, Brazil

Received 6 July 2012; Revised 13 September 2012; Accepted 13 September 2012

Academic Editor: Hartmut Jaeschke

Copyright © 2012 Sandro M. Hirabara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions.

Author: Sandro M. Hirabara, Renata Gorjão, Marco A. Vinolo, Alice C. Rodrigues, Renato T. Nachbar, and Rui Curi



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