In Vivo Delivery of Tinospora cordifolia Root Extract Preventing Radiation-Induced Dystrophies in Mice OvariesReport as inadecuate

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Evidence-Based Complementary and Alternative Medicine - Volume 2015 2015, Article ID 346427, 7 pages -

Research Article

Amity Education Valley, Kant Kalwar, NH-11C, Jaipur Delhi Highway, Jaipur, Rajasthan 303007, India

Department of Zoology, University of Rajasthan, JLN Marg, Jaipur, Rajasthan 302004, India

Received 14 March 2015; Revised 9 July 2015; Accepted 13 July 2015

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2015 Riddhi Sharma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Unconscious and unplanned radiation exposures are a severe threat to gonads particularly ovaries. The present study aims at finding radioprotective effect of Tinospora cordifolia Willd. Miers root extract TCRE in ovaries. Swiss albino mice were divided into four groups: Group 1 served as -normal- and is administered double distilled water and Group 2 is given TCRE with optimum dosage selected as 75 mg-mice. Group 3 serving the purpose of -irradiated control- were exposed to 2.5 Gy gamma radiation. Group 4 experimental were administered optimum dosage of TCRE with prior exposure to 2.5 Gy gamma radiation. Follicle cell counts were scored at autopsy intervals of 24 hrs, 3 days, 7 days, 15 days, and 30 days after gamma irradiation. To understand the mechanism of radioprotection, lipid peroxidation LPO and glutathione GSH levels were also measured in all groups. TCRE supplementation rendered significant protection to ovaries by restoring follicle counts; it also reduced LPO levels and increased GSH levels in ovaries. It implies that TCRE administration protects ovaries against radiation exposure.

Author: Riddhi Sharma



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