Outcomes and Risk Factors Associated with Clostridium difficile Diarrhea in Hospitalized Adult PatientsReport as inadecuate




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Gastroenterology Research and Practice - Volume 2015 2015, Article ID 346341, 6 pages -

Clinical Study

Section of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil

Hospital Infection Control Committee, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil

Received 20 January 2015; Revised 2 May 2015; Accepted 4 May 2015

Academic Editor: Dimitris S. Ladas

Copyright © 2015 Daniela Zilio Larentis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The epidemiology of Clostridium difficile infection has changed over time. Therefore, it is essential to monitor the characteristics of patients at risk of infection and factors associated with poor prognosis. Objective. To evaluate factors associated with C. difficile infection and with poor prognosis in those with documented C. difficile colitis. Methods. A retrospective case-control study of 75 patients with documented C. difficile colitis and 75 controls with hospital-acquired diarrhea of other causes. Stepwise multiple logistic regression was used to identify factors associated with C. difficile infection among patients with hospital-acquired diarrhea. Results. Previous antibiotic treatment odds ratio OR, 13.3; 95% confidence interval CI, 1.40–126.90, abdominal distension OR, 3.85; 95% CI, 1.35–10.98, and fecal leukocytes OR, 8.79; 95% CI, 1.41–54.61 are considered as predictors of C. difficile colitis; anorexia was negatively associated with C. difficile infection OR, 0.15; 95% CI, 0.03–0.66. Enteral tube feeding was independently associated with a composite outcome that included in-hospital mortality, intensive care unit admission, and treatment failure OR, 3.75; 95%CI, 1.24–11.29. Conclusions. Previous antibiotic use and presence of fecal leukocytes in patients with hospital-acquired diarrhea are associated with C. difficile colitis and enteral tube support with complications associated with C. difficile colitis.





Author: Daniela Zilio Larentis, Regis Goulart Rosa, Rodrigo Pires dos Santos, and Luciano Zubaran Goldani

Source: https://www.hindawi.com/



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