Quantification of Rifaximin in Tablets by Spectrophotometric Method Ecofriendly in Ultraviolet RegionReport as inadecuate




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Scientifica - Volume 2016 2016, Article ID 3463405, 9 pages -

Research ArticleDepartment of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista UNESP, Rodovia Araraquara-Jaú, km 1, 14801-902 Araraquara, SP, Brazil

Received 26 December 2015; Accepted 30 May 2016

Academic Editor: Roberta Fruttero

Copyright © 2016 Ana Carolina Kogawa and Hérida Regina Nunes Salgado. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rifaximin is an oral nonabsorbable antibiotic that acts locally in the gastrointestinal tract with minimal systemic adverse effects. It does not have spectrophotometric method ecofriendly in the ultraviolet region described in official compendiums and literature. The analytical techniques for determination of rifaximin reported in the literature require large amount of time to release results and are significantly onerous. Furthermore, they use toxic reagents both for the operator and environment and, therefore, cannot be considered environmentally friendly analytical techniques. The objective of this study was to develop and validate an ecofriendly spectrophotometric method in the ultraviolet region to quantify rifaximin in tablets. The method was validated, showing linearity, selectivity, precision, accuracy, and robustness. It was linear over the concentration range of 10–30 mg L

with correlation coefficients greater than 0.9999 and limits of detection and quantification of 1.39 and 4.22 mg L

, respectively. The validated method is useful and applied for the routine quality control of rifaximin, since it is simple with inexpensive conditions and fast in the release of results, optimizes analysts and equipment, and uses environmentally friendly solvents, being considered a green method, which does not prejudice either the operator or the environment.





Author: Ana Carolina Kogawa and Hérida Regina Nunes Salgado

Source: https://www.hindawi.com/



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