Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for TuberculosisReport as inadecuate

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Tuberculosis Research and TreatmentVolume 2011 2011, Article ID 346295, 7 pages

Research ArticleDivision of Infectious Diseases, Department of Medicine, The Keck School of Medicine and the School of Pharmacy of the University of Southern California, IRD Building, Room 432, 2020 Zonal Avenue, Los Angeles, CA 90033, USA

Received 2 June 2011; Accepted 3 July 2011

Academic Editor: S. G. Franzblau

Copyright © 2011 Alejandro Sanchez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population. Design. Twenty-four patients 23 to 79 years old with pulmonary tuberculosis and inflammation pretreatment albumin  g-dL, C-reactive protein CRP  μg-dL, and beta-2-microglobulin  μg-L were evaluated and had BIA over 24 weeks. Results. Weight increased by  kg 5.5%; at week 4 and by  kg 15.6%; at week 24. Repletion of body mass was primarily fat, which increased by  kg at week 4 and  kg at week 24 and versus baseline. Fat-free mass FFM, body cell mass BCM, and phase angle did not increase until study week 8. Albumin rose to  g-dL by week 4 and slowly increased thereafter. CRP levels declined by ~50% at each interval visit. Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

Author: Alejandro Sanchez, Colleen Azen, Brenda Jones, Stan Louie, and Fred Sattler



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