Fabrication of Gold Nanochains with Octreotide Acetate TemplateReport as inadecuate

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Journal of NanomaterialsVolume 2013 2013, Article ID 346274, 9 pages

Research Article

Applying Chemistry Key Lab of Hebei Province, College of Environmental and Chemical Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China

Oncology Department of Qinhuangdao First Hospital, No. 258 Wenhua Road, Qinhuangdao 066000, China

Received 23 April 2013; Accepted 5 August 2013

Academic Editor: Xinqing Chen

Copyright © 2013 Jing Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We described a facile method for assembly gold nanochains by using octreotide acetate as template in aqueous environment. In acidic solution, octreotide acetate was conferred positive charges and its structure changed to chain-like. The monodisperse negative gold nanoparticles were bound to the surface of octreotide acetate template by electrostatic attraction and the interaction of gold nanoparticles with amino acid residues tryptophan and lysine. The fabricated gold nanostructure presented chain-like observed by transmission electron microscopy. The cytotoxicity of gold nanochains was examined by tetrazolium dye-based microtitration MTT assay, which demonstrated significantly less toxicity than that of octreotide acetate alone. The MTT assay also reflected the combinative action between the gold nanoparticles with octreotide acetate. Our work lays the groundwork for developing octreotide acetate-templated nanomaterials that can be used as a building block for the creation of nanomaterials. Meanwhile, the harmfulless gold nanochains have great application prospects in the biomedical filed.

Author: Jing Zhou, Zhanzhao Fu, Dawei Gao, Faming Gao, Na Li, Xiaoning Zhao, Yanping Liu, Zi Wang, and Guangxia Wang

Source: https://www.hindawi.com/


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