Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis TreatmentReportar como inadecuado




Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Tuberculosis Research and TreatmentVolume 2013 2013, Article ID 285094, 13 pages

Clinical Study

Tropical Disease Department, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP, Brazil

Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP, Rubião Júnior S-N, Botucatu 18618-970, SP, Brazil

Lauro de Souza Lima Institute, Bauru, SP, Brazil

Microbiology and Immunology Department, Bioscience Institute, UNESP, São Paulo State University, Botucatu, SP, Brazil

Nursing Department, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP, Brazil

Dermatology and Radiotherapy Department, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP, Brazil

The Methodist Hospital Research Institute, Houston, TX, USA

Received 19 December 2012; Revised 19 February 2013; Accepted 26 February 2013

Academic Editor: Carlo Garzelli

Copyright © 2013 Eliana Peresi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis PTB at different time points of antituberculosis treatment T1, T2, and T3. Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T-A, IFNG +2109A-G, IL12B +1188A-C, IL10 −819C-T, and TGFB1 +21C-T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.





Autor: Eliana Peresi, Larissa Ragozo Cardoso Oliveira, Weber Laurentino da Silva, Érika Alessandra Pellison Nunes da Costa, João Pe

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados