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Stem Cells InternationalVolume 2016 2016, Article ID 2850873, 6 pages

Review Article

Tianjin Medical University Eye Hospital, Tianjin 300384, China

Nova Southeastern College of Optometry, Fort Lauderdale, FL 33314, USA

Received 18 September 2015; Revised 23 November 2015; Accepted 25 November 2015

Academic Editor: Jeremy M. Crook

Copyright © 2016 Jin Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can be well observed directly after gene therapy or transplantation. The blood-retinal barrier is part of a specialized ocular microenvironment that is immune privileged. This protects transplanted cells and tissue. Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. This review is to present an up-to-date summary of the iPSC’s sources, variations, differentiation methods, and the wide-ranging application of iPSCs-RPCS or iPSCs-RPE on retinal disease modeling, diagnostics, and therapeutics.

Autor: Jin Yang, Bingcui Cai, Patrick Glencer, Zhiqing Li, Xiaomin Zhang, and Xiaorong Li



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