Effect of Albendazole on Human Hydatid Cysts: An Ultrastructural StudyReport as inadecuate

Effect of Albendazole on Human Hydatid Cysts: An Ultrastructural Study - Download this document for free, or read online. Document in PDF available to download.

HPB Surgery - Volume 2 1990, Issue 2, Pages 105-113

Department of Biological Sciences, University of Keele, Staffs. ST5 5BG, United Kingdom

Department of Surgery, University Hospital, Nottingham NG7 2UH, United Kingdom

Received 20 July 1988

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Five patients with hepatic 3, pelvic 1 or spinal 1 hydatid cysts received 10 mg-kg-d albendazole for 1–3months prior to surgery. Daughter cysts were present in the spinal hydatid and in one patient with hepaticdisease. Electron microscope examination of the cyst tissue of the pelvic and the 2 hepatic cysts lackingdaughter cysts showed no evidence of germinal layer, and the protoscoleces were dead. The primary cyst ofthe hepatic hydatid with daughter cysts 1 month therapy was also judged dead but some pieces of thedaughter cyst germinal layer appeared normal and had unaffected protoscoleces. The daughter cyst tissue ofthe spinal hydatid 3 month therapy appeared normal and the protoscoleces viable. In view of theundetermined viability of human hydatids before chemotherapy, treatment of longer than 1 month isadvocated for hepatic cysts, particularly if daughter cysts are present, and longer therapy is indicated forspinal disease.

Author: K. Sylvia Richards and D. L. Morris

Source: https://www.hindawi.com/


Related documents