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Journal of ChemistryVolume 2013 2013, Article ID 893479, 11 pages

Research Article

School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China

Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane QLD 4059, Australia

College of Materials Science and Engineering, Nanjing University of Technology, 5 Xinmofan Road, Nanjing 210009, China

Received 2 May 2013; Revised 16 June 2013; Accepted 17 June 2013

Academic Editor: Nurettin Sahiner

Copyright © 2013 Min Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The magnetic Fe-MBG-C composite scaffolds with enhanced mechanical strength and multifunctionality have been successfully prepared. The study showed that the Fe-MBG-C composite scaffolds with the porosity of ca. 80% had interconnected macropores 200–500 µm and mesopores 3.7–4.4 nm and significantly enhanced the compressive strength compared to the pure MBG scaffolds. Importantly, the Fe-MBG-C composite scaffolds exhibited good bioactivity and sustained drug release property. At the same time, the Fe-MBG-C composite scaffolds could generate heat to raise the temperature of surrounding environment in an alternating magnetic field due to their superparamagnetic behavior. Therefore, the magnetic Fe-MBG-C composite scaffolds could form a multifunctional platform with bone regeneration, magnetic hyperthermia, and local drug delivery and have more potential for use in the regeneration of the critical-sized bone defects caused by bone tumors.





Autor: Min Zhu, Jianhua Zhang, Yinghong Zhou, Yunfei Liu, Xing He, Cuilian Tao, and Yufang Zhu

Fuente: https://www.hindawi.com/



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