Protective and Therapeutic Effects of Chinese Medicine Formula Jiajian Yunvjian on Experimental Cardiac Remodeling after Myocardial Infarction Induced by Coronary Artery LigationReportar como inadecuado




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Evidence-Based Complementary and Alternative Medicine - Volume 2015 2015, Article ID 949656, 9 pages -

Research ArticleDepartment of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received 19 January 2015; Revised 29 May 2015; Accepted 1 June 2015

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2015 Jun Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. This study was designed to explore the effect and mechanism of a classic Chinese medicine formula Jiajian Yunvjian JJYNJ on cardiac remodeling. Cardiac remodeling after myocardial infarction MI model was achieved by coronary artery ligation CAL. Methodology. When dosed orally once daily, the effects of JJYNJ on hemodynamics, left ventricular weight index LVWI, heart weight index HWI, concentration, and gene expression of neuroendocrine factors as well as the histomorphological observation were determined. Results. After 4 weeks, mild cardiac remodeling in CAL group was characterized compared with sham group, but after 4 weeks of treatment of JJYNJ, hemodynamics improved, HWI reduced, and circulating angiotensin II Ang II, endothelin-1 ET-1, tumor necrosis factor-α TNF-α, and hydroxyproline Hyp concentrations as well as Ang II receptor type 1 AT1R mRNA, transforming growth factor β1 TGF-β1 mRNA, and TNF-α mRNA levels in myocardium were lower than in CAL group. Decreased plasma aldosterone ALD concentration, cross-sectional area of cardiomyocyte, collagen volume fraction CVF, collagen types I and III, perivascular collagen area PVCA, and upregulated nitric oxide NO levels were observed at the same time. Conclusions. These findings suggest that JJYNJ may have a protective and therapeutic function on cardiac remodeling related to MI.





Autor: Jun Du, Wei-liang Gu, Chang-xun Chen, Ying Wang, and Jian Lv

Fuente: https://www.hindawi.com/



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