Comparative Pharmacokinetics of Cefquinome Cobactan 2.5% following Repeated Intramuscular Administrations in Sheep and GoatsReportar como inadecuado




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Journal of Veterinary MedicineVolume 2014 2014, Article ID 949642, 5 pages

Research Article

Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, Egypt

Received 28 December 2013; Revised 13 April 2014; Accepted 27 April 2014; Published 19 May 2014

Academic Editor: Nora Mestorino

Copyright © 2014 Mohamed El-Hewaity et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular IM administrations of 2 mg-kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus ATCC 9341 as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats.





Autor: Mohamed El-Hewaity, Amera Abd El Latif, Ahmed Soliman, and Mohamed Aboubakr

Fuente: https://www.hindawi.com/



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