Interaction of XRCC1 Arg399Gln Polymorphism and Alcohol Consumption Influences Susceptibility of Esophageal CancerReportar como inadecuado

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Gastroenterology Research and Practice - Volume 2016 2016, Article ID 9495417, 4 pages -

Research Article

Endoscopic Department, The Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China

Department of Radiology, Armed Police Corps Hospital of Heilongjiang, Harbin, Heilongjiang 150010, China

Department of Radiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150000, China

Received 6 September 2015; Revised 16 December 2015; Accepted 28 December 2015

Academic Editor: Tetsuro Setoyama

Copyright © 2016 Man Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To explore the correlation between the Arg399Gln polymorphism and susceptibility to esophageal cancer in Korean and Han Chinese individuals in Harbin, China, and its potential interaction with alcohol consumption. Methods. This prospective study included 203 patients with esophageal squamous cell carcinoma; 88 were of Korean descent and 115 were of Han Chinese descent. A group of healthy controls included 105 participants of Korean descent and 105 of Han Chinese descent. Genotyping of the Arg399Gln locus of XRCC1 was performed by PCR-RFLP. Results. The allelic and genotypic frequencies were not significantly different between individuals with esophageal cancer and controls or between individuals of Korean and Han Chinese descent . However, when individuals with the wild-type Arg-Arg genotype also consumed alcohol, the risk of esophageal cancer was lower OR = 3.539; 95% CI = 2.039–6.142; . Conclusions. The XRCC1 Arg399Gln polymorphism does not appear to be associated with esophageal cancer in individuals of Korean or Han Chinese descent in Harbin, China. However, alcohol consumption may decrease the risk of esophageal cancer in persons with the wild-type genotype.

Autor: Man Li, Xia Yu, Zhi-yan Zhang, Chun-long Wu, and Hai-long Xu



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