The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino AcidsReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 9318329, 10 pages -

Clinical Study

Dipartimento di Medicina Fisica e Riabilitativa, Salvatore Maugeri Foundation, Centro Medico di Nervi, IRCCS, Fondazione Maugeri, Via Missolungi 14, 16167 Nervi, Italy

Dipartimento di Biologia e Biotecnologie, Unità di Biochimica, Università di Pavia, Via Ferrata 2, 27100 Pavia, Italy

Dipartimento di Scienze del Farmaco, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy

Direzione Scientifica Centrale, IRCCS, Fondazione Maugeri, Via Boezio 28, 27100 Pavia, Italy

Istituto Scientifico di Lumezzane, IRCCS, Fondazione Maugeri, Via Mazzini 129, 25065 Lumezzane, Italy

Consorzio per Valutazioni Biologiche e Farmacologiche, Via Porta 12, 27100 Pavia, Italy

Dipartimento di Medicina Molecolare, Unità di Biochimica, Università di Pavia, Via Taramelli 3-B, 27100 Pavia, Italy

Received 2 October 2015; Revised 22 February 2016; Accepted 6 March 2016

Academic Editor: Jozef Zustin

Copyright © 2016 Eleonora Baldissarro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is not known whether postsurgery systemic inflammation and plasma amino acid abnormalities are still present during rehabilitation of individuals after elective hip arthroplasty EHA. Sixty subjects 36 females; age years were randomized to receive 14-day oral EAAs 8 g-day or a placebo maltodextrin. At admission to and discharge from the rehabilitation center, serum C-reactive protein CRP and venous plasma amino acid concentrations were determined. Post-EHA hip function was evaluated by Harris hip score HHS test. Ten matched healthy subjects served as controls. At baseline, all patients had high CRP levels, considerable reduction in several amino acids, and severely reduced hip function HHS scores. After treatment, inflammation decreased both in the EAA group and in the placebo group. Only EAA patients significantly improved their levels of glycine, alanine, tyrosine, and total amino acids. In addition, they enhanced the rate of hip function recovery HHS from baseline to versus baseline to in placebo one; . The study documents the persistence of inflammation and plasma amino acid abnormalities in post-EHA rehabilitation phase. EAAs enhance hip function retrieval and improve plasma amino acid abnormalities.





Autor: Eleonora Baldissarro, Roberto Aquilani, Federica Boschi, Paola Baiardi, Paolo Iadarola, Marco Fumagalli, Evasio Pasini, Man

Fuente: https://www.hindawi.com/



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