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Abstract: New models for evolutionary processes of mutation accumulation allowhypotheses about the age-specificity of mutational effects to be translatedinto predictions of heterogeneous population hazard functions. We apply thesemodels to questions in the biodemography of longevity, including proposedexplanations of Gompertz hazards and mortality plateaus, and use them toexplore the possibility of melding evolutionary and functional models of aging.



Autor: Kenneth W. Wachter, David R. Steinsaltz, Steven N. Evans

Fuente: https://arxiv.org/







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