IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian PatientsReportar como inadecuado




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Mediators of Inflammation - Volume 2015 2015, Article ID 819149, 5 pages -

Research Article

Laboratório de Imunomodulação e Novas Abordagens Terapêuticas LINAT, Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino NUPIT-SG, Universidade Federal de Pernambuco UFPE, Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil

Hospital das Clínicas, Universidade Federal de Pernambuco UFPE, Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil

Received 11 May 2015; Revised 13 July 2015; Accepted 22 July 2015

Academic Editor: Anshu Agrawal

Copyright © 2015 Priscilla Stela Santana de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokine detection. Psoriasis Area and Severity Index PASI was assessed at the time of sampling in psoriasis patients. Our findings demonstrate that IL-17A, IL-22, and IL-6 serum concentrations were significantly higher in psoriasis patients than in the control group. No statistical correlation could be found between cytokines concentrations, PASI score, and age in this study. Although our results do not show any correlation between serum levels of IL-17A, IL-22, and IL-6 and disease activity, the present study confirms that they were increased in Brazilian psoriasis patients in comparison to healthy volunteers.





Autor: Priscilla Stela Santana de Oliveira, Pablo Ramon Gualberto Cardoso, Emerson Vasconcelos de Andrade Lima, Michelly Cristiny Pere

Fuente: https://www.hindawi.com/



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