Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-PeptideReportar como inadecuado

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Experimental Diabetes ResearchVolume 2008 2008, Article ID 819123, 2 pages

Review ArticleFirst Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-Machi, Takatsuki 569-8686, Japan

Received 27 November 2007; Accepted 26 February 2008

Academic Editor: Thomas Forst

Copyright © 2008 Yuko Murase-Mishiba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with fulminant type 1 diabetes almost completely lackC-peptide even soon after the onset of the disease, and the deficiencycontinues for the rest of their life. Thus, fulminant type 1 diabetescould serve as a good model of nature to explore the physiological roleof C-peptide. For example, patients with fulminant type 1 diabetes havediabetic chronic complications more frequently than those with classicalautoimmune type 1 diabetes 5 years after the onset of diabetes, and thehigher prevalence could be partly attributable to the complete lack ofC-peptide in fulminant type 1 diabetes.

Autor: Yuko Murase-Mishiba, A. Imagawa, and Toshiaki Hanafusa

Fuente: https://www.hindawi.com/


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