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BMC Pulmonary Medicine

, 14:205

Infectious, Rare and Idiopathic Pulmonary Diseases


BackgroundEpidemiological studies report high rates of depression among patients with cystic fibrosis CF. Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years.

MethodsIn the context of the TIDES study, 473 German patients with CF age 12–53 years, FEV1% predicted M = 66.2, range 13–137 completed the Hospital Anxiety and Depression Scale HADS. Lung function FEV1% predicted was assessed at baseline and followed up two years later. Repeated measures analysis was performed involving the level of FEV1% and the level of depressive symptoms at baseline as independent factors and FEV1% at the 2-year follow-up as the dependent variable.

ResultsInteraction between lung function and depression at baseline significantly affected the change in lung function at the 2-years observation interval. The largest decline in FEV1% occurred in depressed patients with good lung function at baseline. In contrast, patients without any clinically relevant depressive symptoms and with poor lung function at baseline showed a slight increase two years later.

ConclusionThe findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression.

KeywordsCystic fibrosis Depression Lung function Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-205 contains supplementary material, which is available to authorized users.

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Autor: Astrid Fidika - Marion Herle - Lutz Goldbeck


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