Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-α2-glycoprotein ZAG are inhibited in early sepsis, but increase with clinical recovery: a pilot studyReportar como inadecuado




Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-α2-glycoprotein ZAG are inhibited in early sepsis, but increase with clinical recovery: a pilot study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Anesthesiology

, 14:124

Critical care

Abstract

BackgroundAdipose tissue has been identified as an endocrine organ secreting adipokines involved in metabolic and inflammatory pathways. Adiponectin, an anti-inflammatory adipokine, is reduced in sepsis. High Molecular Weight HMW adiponectin, the biologically most relevant molecule, has been investigated very little in human sepsis. Zinc-alpha2-glycoprotein ZAG is a novel adipokine and its expression in adipose tissue is positively correlated with adiponectin expression. It is not yet known whether ZAG has a role in sepsis. In this study we assessed levels of HMW adiponectin and ZAG during different stages of sepsis.

MethodsA prospective observational pilot study was carried out on 21 septic patients. Serum samples were taken on day 1 and 2 post ICU admission and on day of discharge. Samples were analysed for total and HMW adiponectin, HMW-total adiponectin ratio, and ZAG. Results were correlated with clinical and metabolic data.

ResultsThere were no differences in total adiponectin, HMW adiponectin and ZAG plasma concentrations between day 1 admission and day 2 of the sepsis episode. Compared to admission, a significant increase in total and HMW adiponectin and ZAG was observed on the day of discharge when clinical improvement had been achieved. There was also an increase in the HMW-total adiponectin ratio at that time.

ConclusionsOur data demonstrate an increase in both HMW adiponectin and total adiponectin in patients who had clinically recovered from sepsis. The increase in HMW-total adiponectin ratio with improvement of the clinical condition suggests that HMW adiponectin may have a greater role in the inflammatory process and insulin resistance seen in sepsis. In this pilot study, we have also demonstrated a significant increase in ZAG in critically ill patients temporally related to recovery from sepsis.

KeywordsAdiponectin HMW adiponectin Zinc-α2-glycoprotein Sepsis Adipokines AbbreviationsAPACHE IIAcute physiology and Chronic Health evaluation Score

BSABovine Serum Albumin

CRPC-reactive protein

HMWHigh molecular weight

ICUIntensive Care Unit

PBSPhosphate buffered saline

WATWhite adipose tissue

WCCWhite cell count

ZAGZinc-α2-glycoprotein.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2253-14-124 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Ingeborg D Welters - Chen Bing - Cherlyn Ding - Martin Leuwer - Alison M Hall

Fuente: https://link.springer.com/







Documentos relacionados