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BMC Pulmonary Medicine

, 14:206

Epidemiology and public health

Abstract

BackgroundThe association between impaired lung function and cardiovascular disease CVD risk factors has been shown in adults. However, there is little evidence of such an association in young adults, particularly from South America, where the burden of CVD and chronic obstructive pulmonary disease COPD is as high as that observed in more developed countries. We therefore investigated the relation between CVD risk factors including metabolic syndrome MS, and lung function status in young adults from Chile.

Methods970 subjects from a sample of 998 adults born between 1974 and 1978 in Limache, Chile, were studied. A Spanish translation of the European Community Respiratory Health Survey ECRHS questionnaire was used. Forced expiratory volume in 1 second FEV1 and forced vital capacity FVC were measured. Weight, height, waist circumference WC, blood pressure, Homeostatic model assessment HOMA-IR, triglycerides, high density lipoprotein HDL, glycaemia, and metabolic syndrome MS were also assessed.

ResultsThe prevalence of MS was 11.8%. A lower FEV1 and lower FVC were associated with having MS β-coefficient -0.13; 95% Confidence Interval CI -0.21 to -0.05, and β-coefficient -0.18; 95% CI -0.27 to -0.09, respectively. Both spirometric measures were also negatively associated with having an elevated HOMA-IR β-coefficient for FEV1 -0.08; 95% CI -0.13 to -0.03, and β-coefficient for FVC -0.11; 95% CI -0.17 to -0.05. In males only, a lower FEV1 and FVC were associated with having elevated triglycerides β-coefficient highest vs. lowest tertile -0.13, 95% CI -0.24 to -0.03, and β-coefficient -0.13, 95% CI -0.25 to -0.01, respectively. In women, a higher FEV1 and FVC were statistically significantly related to having higher levels of HDL. Ventilatory function was unrelated to hypertension or WC in this population.

ConclusionIn this population-based study of young adults, a poorer ventilatory function was associated with many CVD risk factors. Endeavours to understand better causality issues of such associations are warranted.

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Autor: Vanessa Garcia-Larsen - Patricia Bustos - Hugo Amigo - James Potts - Roberto J Rona

Fuente: https://link.springer.com/







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