Ringer’s lactate, but not hydroxyethyl starch, prolongs the food intolerance time after major abdominal surgery; an open-labelled clinical trialReportar como inadecuado




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BMC Anesthesiology

, 15:72

Perioperative medicine and outcome

Abstract

BackgroundThe infusion of large amounts of Ringer’s lactate prolongs the functional gastrointestinal recovery time and increases the number of complications after open abdominal surgery. We performed an open-labelled clinical trial to determine whether hydroxyethyl starch or Ringer’s lactate exerts these adverse effects when the surgery is performed by laparoscopy.

MethodsEighty-eight patients scheduled for major abdominal cancer surgery 83% by laparoscopy received a first-line fluid treatment with 9 ml-kg of either 6% hydroxyethyl starch 130-0.4 Voluven or Ringer’s lactate, just after induction of anaesthesia; this was followed by a second-line infusion with 12 ml-kg of either starch or Ringer’s lactate over 1 hour. Further therapy was managed at the discretion of the attending anaesthetist. Outcome data consisted of postoperative gastrointestinal recovery time, complications and length of hospital stay.

ResultsThe order of the infusions had no impact on the outcome. Both the administration of ≥ 2 L of Ringer’s lactate and the development of a surgical complication were associated with a longer time period of paralytic ileus and food intolerance two-way ANOVA, P < 0.02, but only surgical complications prolonged the length of hospital stay P < 0.001. The independent effect of Ringer’s lactate and complications of food intolerance time amounted to 2 days each. The infusion of ≥ 1 L of hydroxyethyl starch did not adversely affect gastrointestinal recovery.

ConclusionsRinger’s lactate, but not hydroxyethyl starch, prolonged the gastrointestinal recovery time in patients undergoing laparoscopic cancer surgery. Surgical complications prolonged the hospital stay.

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Autor: Yuhong Li - Rui He - Xiaojiang Ying - Robert G Hahn

Fuente: https://link.springer.com/



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