Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltrationReportar como inadecuado




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Journal of Intensive Care

, 3:22

First Online: 08 May 2015Received: 10 January 2015Accepted: 23 April 2015

Abstract

The aim of this study was to establish the pharmacokinetics of levofloxacin LVFX and determine the optimal dose of this drug in critically ill patients receiving continuous hemodiafiltration CHDF. The results of in vivo and in vitro studies showed the pharmacokinetics of LVFX total clearance CLtotal according to the creatinine clearance CLCre, dialysate flow QD, and ultrafiltrate flow QF, to be as follows: CLtotal l-h = 0.0836 × CLCre ml-min + 0.013 × body weight kg + 0.94QD + QF l-h. The optimal dose of LVFX was expressed by the following formula: 50 × CLtotal. These results demonstrate that the usual dose of LVFX 500 mg was sufficient for the patients evaluated in this study.

KeywordsLevofloxacin Pharmacokinetics Continuous hemodiafiltration Clearance AbbreviationsLVFXlevofloxacin

CHDFcontinuous hemodiafiltration

CLCrecreatinine clearance

QDdialysate flow

QFultrafiltrate flow

CLtotalLVFX total clearance

PKPharmacokinetics

FFPfresh frozen plasma

SCsieving coefficient

CLCHDFclearance by CHDF

CLvivoclearance in patients

BWbody weight

AUCarea under the concentration-time curve

MICminimum inhibitory concentration

CPFXciprofloxacin

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Autor: Takeshi Wada - Masaki Kobayashi - Yuichi Ono - Asumi Mizugaki - Kenichi Katabami - Kunihiko Maekawa - Daisuke Miyamoto - Yu

Fuente: https://link.springer.com/







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