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Intensive Care Medicine

, Volume 41, Issue 9, pp 1529–1537

A global inception cohort studyFirst Online: 11 July 2015Received: 16 March 2015Accepted: 27 April 2015


BackgroundFluid challenges FCs are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.

MethodsThis was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC.

Results2213 patients were enrolled and analyzed in the study. The median interquartile range amount of fluid given during an FC was 500 ml 500–1000. The median time was 24 min 40–60 min, and the median rate of FC was 1000 500–1333 ml-h. The main indication for FC was hypotension in 1211 59 %, CI 57–61 %. In 43 % CI 41–45 % of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases 36 %, CI 34–37 %. Dynamic indices of preload responsiveness were used in 483 of 2213 cases 22 %, CI 20–24 %. No safety variable for the FC was used in 72 % CI 70–74 % of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response.

ConclusionsThe current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account.

Electronic supplementary materialThe online version of this article doi:10.1007-s00134-015-3850-x contains supplementary material, which is available to authorized users.

The FENICE investigators are listed in full in ESM 2 National Coordinators and ESM 4 Steering Committee, Study Statistician, Study Coordinator and Local Investigators.

Trial registration: ClinicalTrials.Gov NCT01787071.

An erratum to this article can be found at http:-dx.doi.org-10.1007-s00134-015-4003-y.

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Autor: Maurizio Cecconi - Christoph Hofer - Jean-Louis Teboul - Ville Pettila - Erika Wilkman - Zsolt Molnar - Giorgio Della Rocca

Fuente: https://link.springer.com/

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