Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy in Cypriot adolescents: a case–control studyReportar como inadecuado




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Multidisciplinary Respiratory Medicine

, 10:26

First Online: 04 September 2015Received: 11 June 2015Accepted: 31 July 2015

Abstract

BackgroundPolymorphisms in the vitamin D receptor VDR gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D and VDR have been independently linked to asthma susceptibility. We investigated whether VDR variants were associated independently or in relation to vitamin D levels with asthma in Cypriot adolescents.

MethodsWe studied 190 current wheezers, 69 of which were categorized as active asthmatics and 671 healthy controls. We determined three VDR genotypes BsmI, TaqI, ApaI and measured serum 25OHD levels. Logistic regression and stratified analyses by the presence of hypovitaminosis D ≤20 ng-ml were used to evaluate the association of the VDR variants with asthma.

ResultsThe distribution of TaqI genotypes was significantly different between controls and current wheezers p = 0.030 or active asthmatics p = 0.014. The tt genotype was over-represented in wheezers 19.2 % and asthmatics 21.3 % compared to respective controls 12.9 %. No difference was observed between controls, current wheezers and active asthmatics in the genotypic distribution of BsmI and ApaI polymorphic sites. After stratification by the presence of hypovitaminosis D, a significant association was detected between tt genotype of TaqI polymorphism with wheezing OR: 1.97, 95 % CI: 1.12, 3.46 and asthma OR: 2.37, 95CI%: 1.02, 5.52 only in those with normal vitamin D levels >20 ng-ml but not in subjects with low vitamin D.

ConclusionsThe minor TaqI genotype of VDR is associated with asthma in Cypriot adolescents. This polymorphism may contribute to asthma susceptibility primarily under conditions of normal vitamin D levels >20 ng-ml.

KeywordsVitamin D VDR Asthma Polymorphisms Adolescents AbbreviationsCUWCurrent Wheezers

CUWACurrent Wheezing and Asthma

ISAACInternational Study of Asthma and Allergies in Childhood

NWNANever Wheezers Never Asthmatics

SPTSkin prick tests

VDRVitamin D receptor

Electronic supplementary materialThe online version of this article doi:10.1186-s40248-015-0025-0 contains supplementary material, which is available to authorized users.

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Autor: Anna Papadopoulou - Panayiotis Kouis - Nikos Middleton - Ourania Kolokotroni - Themistokles Karpathios - Polyxeni Nicolaidou

Fuente: https://link.springer.com/







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