Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult CancerReportar como inadecuado




Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2016 2016, Article ID 9363951, 8 pages -

Research Article

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

Weill Cornell Medical Center, New York, NY 10065, USA

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

Received 15 October 2015; Accepted 11 January 2016

Academic Editor: Giovanni Di Salvo

Copyright © 2016 Anthony F.
Yu et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two-dimensional speckle tracking echocardiography 2DSTE provides a sensitive measure of left ventricular LV systolic function and may aid in the diagnosis of cardiotoxicity.
2DSTE was performed in a cross-sectional study of 134 patients mean age: years; 55% male; mean time since diagnosis: years previously treated with anthracyclines mean cumulative dose:  mg-m

, with or without mediastinal radiotherapy.
The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction LVEF < 55%, and global longitudinal strain GLS ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively.
Abnormal GLS was observed in 24 18% patients despite a normal LVEF.
Indices of LV systolic function were similar regardless of anthracycline dose.
However, GLS was worse 18.0 versus 19.0, and prevalence of abnormal GLS was higher 36.5% versus 14.6%, in patients treated with mediastinal radiotherapy.
Mediastinal radiotherapy was associated with reduced GLS after adjusting for sex, age, and cumulative anthracycline dose.
In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors.






Autor: Anthony F.
Yu, Jayant Raikhelkar, Emily C.
Zabor, Emily S.
Tonorezos, Chaya S.
Moskowitz, Roberto Adsuar, Elton Mara, Kevin


Fuente: https://www.hindawi.com/



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