Efficacy and Tolerability of Telmisartan Plus Amlodipine in Asian Patients Not Adequately Controlled on Either Monotherapy or on Low-Dose Combination TherapyReportar como inadecuado




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International Journal of Hypertension - Volume 2014 2014, Article ID 475480, 11 pages -

Research Article

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Hypertension, 197 Ruijin Road, Shanghai 200025, China

Nippon Boehringer Ingelheim Co., Ltd , 2-1-1, Osaki, Shinagawa-ku, Tokyo 141-6017, Japan

Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Straße 173, 55216 Ingelheim, Germany

Received 6 November 2013; Accepted 15 January 2014; Published 27 February 2014

Academic Editor: Claudio Borghi

Copyright © 2014 Dingliang Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the efficacy and safety of the telmisartan plus amlodipine T-A single-pill combination SPC in Asian patients with hypertension whose blood pressure BP was not adequately controlled on either monotherapy or on low-dose combination therapy. Patients and Methods. Data are presented from five Boehringer Ingelheim-sponsored phase 3, double-blind, 8-week, studies: two studies in nonresponders to amlodipine data pooled for amlodipine, two studies on nonresponders to telmisartan pooled data, and one on nonresponders to low-dose T-A SPC. Results. After 8 weeks’ treatment, mean reductions from the reference baseline in diastolic BP DBP; primary endpoint, systolic BP SBP, and SBP, DBP goal, and response rates were higher with the T-A SPC than respective monotherapies. The T80-A5 SPC resulted in greater reductions in DBP and SBP, and higher DBP goal and response rate than the low-dose T40-A5 SPC. Peripheral edema incidence was low amlodipine 0.5%, telmisartan 0.0%, and T-A SPC 0.7%. Discussion and Conclusion. In Asian patients whose BP is not adequately controlled with telmisartan or amlodipine monotherapy, T-A SPC treatment results in greater BP reduction, and higher DBP and SBP goal and response rates. The safety and tolerability of the T-A SPC are comparable to those of the respective monotherapies and consistent with those reported in previous studies.





Autor: Dingliang Zhu, Pingjin Gao, Nobutaka Yagi, and Helmut Schumacher

Fuente: https://www.hindawi.com/



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