Periostin levels and eosinophilic inflammation in poorly-controlled asthmaReport as inadecuate

Periostin levels and eosinophilic inflammation in poorly-controlled asthma - Download this document for free, or read online. Document in PDF available to download.

BMC Pulmonary Medicine

, 16:67

Asthma and allergic disorders


BackgroundPeriostin levels are associated with airway eosinophilia and are suppressed by corticosteroid treatment in asthma. This study sought to determine the relationship between serum and sputum periostin, airway inflammatory phenotype and asthma control.

MethodsAdults with poorly-controlled asthma n = 83 underwent a clinical assessment, sputum induction and blood sampling. Dispersed sputum was used for a differential cell count and periostin assessment ELISA. Serum periostin was determined by the Elecsys® immunoassay.

ResultsPeriostin levels were significantly higher in serum median IQR of 51.6 41.8, 62.6 ng-mL than in sputum 1.1 0.5, 2.0 ng-mL p < 0.001. Serum and sputum periostin were significantly higher in patients with eosinophilic asthma n = 37 compared with non-eosinophilic asthma. Both serum and sputum periostin levels were significantly associated with proportion of sputum eosinophils r = 0.422, p < 0.001 and r = 0.364, p = 0.005 respectively but were not associated with asthma control. In receiver operator characteristic curve analysis, the area under the curve AUC for serum periostin n = 83 was 0.679, p = 0.007. Peripheral blood eosinophils assessed in 67 matched samples, had a numerically greater AUC of 0.820 compared with serum periostin, p = 0.086 for the detection of eosinophilic asthma.

ConclusionIn poorly-controlled asthma, sputum and serum periostin levels are significantly related to sputum eosinophil proportions while their ability to predict the presence of eosinophilic asthma is modest.

KeywordsPeriostin Eosinophilic asthma Non-eosinophillic asthma Phenotype Inflammation AbbreviationACQ6Asthma Control Questionnaire 6

AUCarea under curve

BALbronchoalveolar lavage

BMIbody mass index


FeNOfractional exhaled nitric oxide

FEV1forced expiratory volume in 1 s

ICSinhaled corticosteroids

IQRinterquartile range

ppmparts per million

Th2T-helper 2 cells

Electronic supplementary materialThe online version of this article doi:10.1186-s12890-016-0230-4 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Author: Jodie L. Simpson - Ian A. Yang - John W. Upham - Paul N. Reynolds - Sandra Hodge - Alan L. James - Christine Jenkins -


Related documents