Change in Pseudomonas aeruginosa prevalence in cystic fibrosis adults over timeReport as inadecuate

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BMC Pulmonary Medicine

, 16:176

Epidemiology and public health


BackgroundLittle is known about risk factors for chronic and mucoid Pseudomonas aeruginosa Pa infection in cystic fibrosis CF adults, and whether the prevalence is changing.

MethodsWe employed a retrospective cohort to analyze data from a single adult CF center 2002 to 2012. Regression models were used to assess independent predictors and change in prevalence of chronic and mucoid Pa infection over time.

ResultsThe odds ratio of mucoid Pa infection was significantly less in individuals with better baseline lung function OR 0.84,95%CI:0.77–0.92 and those diagnosed after the age of 25 OR 0.21, 95%CI:0.05–0.95. The prevalence of chronic Pa and mucoid Pa decreased during the time interval. After adjusting for confounders, the observed decrease in chronic and mucoid Pa between 2002 and 2012 was no longer significant.

ConclusionsThe prevalence of chronic and mucoid Pa is decreasing. Larger studies are needed to confirm these regional trends and their significance.

KeywordsCystic fibrosis Pseudomonas aeruginosa Chronic infection Epidemiology Temporal trends AbbreviationsCFCystic Fibrosis

CFRDCystic fibrosis related diabetes

CFTRCystic fibrosis transmembrane conductance regulator

FEV1Forced expiratory volume in one second

GEEGeneralized estimating equation

PaPseudomonas aeruginosa

PIPancreatic insufficiency

Electronic supplementary materialThe online version of this article doi:10.1186-s12890-016-0333-y contains supplementary material, which is available to authorized users.

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Author: Mathew R. Crull - Kathleen J. Ramos - Ellen Caldwell - Nicole Mayer-Hamblett - Moira L. Aitken - Christopher H. Goss


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