The role of osmolality in saline fluid nebulization after tracheostomy: time for changingReportar como inadecuado

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BMC Pulmonary Medicine

, 16:179

Respiratory critical care


BackgroundSaline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear.

ObjectivesTo investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy.

MethodsSprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy SEM.

ResultsStudy results revealed that tracheostomy gave rise to the increase of sputum viscosity, TNF-α and AQP4 expression, mucosa and cilia damage, yet the saline fluid nebulization could significantly decrease the changes of those indicators, besides, the hypertonic, isotonic and hypertonic saline nebulization produced different efficacy.

ConclusionsOsmolality plays an important role in the saline fluid nebulization after tracheostomy, and 3% saline fluid nebulization seems to be more beneficial, further studies on the role of osmolality in saline fluid nebulization are warranted.

KeywordsCare Complication Nebulization Osmolality Saline Tracheostomy AbbreviationsASLAirway surface liquid

BALFBronchoalveolar lavage fluid

CBFCiliary beat frequency

ICUsIntensive care units

SEMScanning electron microscopy

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Autor: Zunjia Wen - Chao Wu - Feifei Cui - Haiying Zhang - Binbin Mei - Meifen Shen


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