Complete Histological Resolution of Collagenous SprueReportar como inadecuado

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Canadian Journal of Gastroenterology - Volume 18 2004, Issue 5, Pages 333-336

Brief Communication

Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada

Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

Shuswap Lake General Hospital, Salmon Arm, British Columbia, Canada

Received 20 January 2004; Accepted 19 March 2004

Copyright 2004 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


A 65-year-old woman developed a watery diarrhea syndrome with collagenous colitis. Later, weight loss and hypoalbuminemia were documented. This prompted small bowel biopsies that showed pathological changes of collagenous sprue. An apparent treatment response to a gluten-free diet and prednisone resulted in reduced diarrhea, weight gain and normalization of serum albumin. Later repeated biopsies from multiple small and large bowel sites over a period of over three years, however, showed reversion to normal small intestinal mucosa but persistent collagenous colitis. These results indicate that collagenous inflammatory disease may be a far more extensive process in the gastrointestinal tract than is currently appreciated. Moreover, collagenous colitis may be a clinical signal that occult small intestinal disease is present. Finally, collagenous sprue may, in some instances, be a completely reversible small intestinal disorder.

Autor: Hugh J Freeman, Jennifer E Davis, and Danny M Myers



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