The CYBA Gene 49A>G Polymorphism rs7195830 Is Associated with Hypertension in Patients with Coronary Artery DiseaseReportar como inadecuado

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BioMed Research International - Volume20162016, Article ID1539671, 7 pages -

Research Article

School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykw Street 18, 40-752 Katowice, Poland

School of Medicine and Division of Dentistry in Zabrze, Department of Internal Medicine, Diabetes and Nephrology, Medical University of Silesia, 3 Maja Street 13-18, 41-800 Zabrze, Poland

1st Department of Cardiac Surgery-2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej Street 101, 43-316 Bielsko-Biala, Poland

Regional Centre of Blood Donation and Blood Treatment in Raciborz, Sienkiewicza Street 3, 47-400 Raciborz, Poland

Received 2 February 2016; Accepted 4 May 2016

Academic Editor: Sanjay K.Banerjee

Copyright 2016 Tomasz Nowak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease CAD. The aim of the present study was to investigate whether the 49A>G rs7195830 polymorphism is associated with CAD. Materials and Methods. CYBA gene 49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results. The frequency of the 49G allele carrier state was significantly higher in patients than in controls 84.8% versus 76.6%, resp., , as well as the frequency of the 49G allele 62.2% versus 54.0%, . Both factors were associated with CAD in the analyzed population OR = 1.70, 95% CI: 1.042.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.081.83 for 49G versus49A. Carrier state of the 49G allele was a stronger and independent risk factor for CAD among women OR = 4.35, 95% CI: 1.5013.20, , as well as the 49G allele OR = 2.25, 95% CI: 1.343.77, . The 49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease . Conclusion. The CYBA gene 49A>G polymorphism modifies the risk of coronary artery disease.

Autor: Tomasz Nowak,Pawe Niemiec,Sylwia Grczyska-Kosiorz,Anna Balcerzyk,Tomasz Iwanicki,Jolanta Krauze,Wladyslaw Grzeszczak,Anna Ochalska



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