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Science China Life Sciences

, Volume 55, Issue11, pp 968973

First Online: 20 November 2012Received: 04 June 2012Accepted: 23 October 2012DOI: 10.1007-s11427-012-4399-3

Cite this article as: Li, M., Liu, L., Xi, N.
et al.
Sci.
China Life Sci.
2012 55: 968.
doi:10.1007-s11427-012-4399-3

Abstract

Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life.
Atomic force microscopy AFM enables researchers to measure mechanical properties of single living cells under physiological conditions.
Here, AFM was used to investigate the topography and mechanical properties of red blood cells RBCs and three types of aggressive cancer cells Burkitts lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562.
The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a micro-sphere glued onto a tip-less cantilever.
The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Youngs modulus of RBCs is smaller than those of the cancer cells.
Aggressive cancer cells have a lower Youngs modulus than that of indolent cancer cells, which may improve our understanding of metastasis.

Keywordsatomic force microscopyred blood cellcancer cellmechanical propertiesYoungs modulusThis article is published with open access at Springerlink.com

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Autor: MiLi - LianQingLiu - NingXi - YueChaoWang - ZaiLiDong - XiuBinXiao - WeiJingZhang

Fuente: https://link.springer.com/



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