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Journal of Addiction - Volume20162016, Article ID1539096, 7 pages -

Research Article

Service Addictologie, Hpital du Grau du Roi, CHU Caremeau, Nmes, France

Dpartement dInformation Scientifique et de Communication DISC, Inserm, Paris, France

Universit Montpellier I, Montpellier, France

Service de Mdecine Interne et Addictologie, Hpital Saint Eloi, Montpellier, France

Inserm U1178, Paris, France

Received 25 July 2016; Revised 10 October 2016; Accepted 8 November 2016

Academic Editor: Rebecca J.Houston

Copyright 2016 Stphanie Pelletier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Cognitive dysfunction is a common feature in alcohol use disorders. Its persistence following alcohol detoxification may impair quality of life and increase the risk of relapse. We analyzed cognitive impairment changes using the Montreal Cognitive Assessment MoCA score in a large sample of alcohol-dependent inpatients hospitalized for at least 4 weeks. Method. This was an observational longitudinal survey. Inclusion criteria were alcohol dependence DSM-IV and alcohol abstinence for at least one week. The MoCA test was administered on admission and at discharge. Results. 236 patients were included. The mean MoCA score significantly increased from on admission to at discharge. The corresponding effect-size of improvement was high, 1.1 95% CI 1.01.2. The degree of improvement was inversely correlated with the baseline MoCA score. The rate of high and normal, that is, >26, MoCA values increased from 15.8% on admission to 53.8% at discharge. MoCA score improvement was not correlated with the total length of abstinence prior to admission. Conclusion. The MoCA score seems to be a useful tool for measuring changes in cognitive performance in alcohol-dependent patients. A significant improvement in cognitive function was observed whatever the degree of impairment on admission and even after a long abstinence period.

Autor: Stphanie Pelletier,Bertrand Nalpas,Rgis Alarcon,Hlne Rigole,and Pascal Perney



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