Role of metallothioneins in benign and malignant thyroid lesionsReportar como inadecuado

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Thyroid Research

, 5:26

First Online: 28 December 2012Received: 17 December 2012Accepted: 18 December 2012DOI: 10.1186-1756-6614-5-26

Cite this article as: Pula, B., Domoslawski, P., Podhorska-Okolow, M. et al. Thyroid Res 2012 5: 26. doi:10.1186-1756-6614-5-26


Recent findings in the past two decades have brought many insights into the biology of thyroid benign and malignant lesions, in particular the papillary and follicular thyroid cancers. Although, much progress have been made, thyroid cancers still pose diagnostic problems regarding differentiation of follicular lesions in relation to their aggressiveness and the treatment of advanced and undifferentiated thyroid cancers. Metallothioneins MTs were shown to induce cancer cells proliferation, mediate resistance to apoptosis, certain chemotherapeutics and radiotherapy. Therefore, MTs may be of utility in diagnosis and management of patients with benign and malignant lesions of the thyroid.

KeywordsMetallothioneinThyroidNodular goiterCancerElectronic supplementary materialThe online version of this article doi:10.1186-1756-6614-5-26 contains supplementary material, which is available to authorized users.

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Autor: BartoszPula - PawelDomoslawski - MarzenaPodhorska-Okolow - PiotrDziegiel


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