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Science China Life Sciences

, Volume 56, Issue 4, pp 384–390

First Online: 07 April 2013Received: 31 October 2012Accepted: 21 December 2012DOI: 10.1007-s11427-013-4467-3

Cite this article as: Wang, J. & Yin, C. Sci. China Life Sci. 2013 56: 384. doi:10.1007-s11427-013-4467-3


Cryo-electron microscopy cryo-EM plays an important role in determining the structure of proteins, viruses, and even the whole cell. It can capture dynamic structural changes of large protein complexes, which other methods such as X-ray crystallography and nuclear magnetic resonance analysis find difficult. The signal-to-noise ratio of cryo-EM images is low and the contrast is very weak, and therefore, the images are very noisy and require filtering. In this paper, a filtering method based on non-local means and Zernike moments is proposed. The method takes into account the rotational symmetry of some biological molecules to enhance the signal-to-noise ratio of cryo-EM images. The method may be useful in cryo-EM image processing such as the automatic selection of particles, orientation determination, and the building of initial models.

Keywordscryo-electron microscopy non-local means Zernike moments rotational symmetry This article is published with open access at Springerlink.com

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Autor: Jia Wang - ChangCheng Yin

Fuente: https://link.springer.com/

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