Control mechanism for the upper airway collapse in patients with obstructive sleep apnea syndrome: a finite element studyReportar como inadecuado




Control mechanism for the upper airway collapse in patients with obstructive sleep apnea syndrome: a finite element study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Science China Life Sciences

, Volume 56, Issue 4, pp 366–372

First Online: 12 March 2013Received: 28 September 2012Accepted: 10 January 2013DOI: 10.1007-s11427-013-4448-6

Cite this article as: Huang, R., Li, X. & Rong, Q. Sci. China Life Sci. 2013 56: 366. doi:10.1007-s11427-013-4448-6

Abstract

Obstructive sleep apnea syndrome OSAS is characterized by recurrent collapses of the upper airway, which lead to repetitive transient hypoxia, arousals and finally sleep fragmentation. Both anatomical and neuromuscular factors may play key roles in the pathophysiology of OSAS. The purpose of this paper was to study the control mechanism of OSAS from the mechanical point of view. A three-dimensional finite element model was developed, which not only reconstructed the realistic anatomical structure of the human upper airway, but also included surrounding structures such as the skull, neck, hyoid, cartilage and soft tissues. The respiration process during the normal and apnea states was simulated with the fluid-structure interaction method FSI and the computational fluid dynamics method CFD. The airflow and deformation of the upper airway obtained from the FSI and the CFD method were compared and the results obtained under large negative pressure during an apnea episode were analyzed. The simulation results show that the FSI method is more feasible and effective than the CFD method. The concave configuration of the upper airway may accelerate the collapse of the upper airway in a positive feedback mechanism, which supplies meaningful information for clinical treatment and further research of OSAS.

Keywordsupper airway collapse sleep apnea FEM fluid-structure interaction This article is published with open access at Springerlink.com

Download to read the full article text



Autor: RenHan Huang - XiPing Li - QiGuo Rong

Fuente: https://link.springer.com/







Documentos relacionados