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Infectious Agents and Cancer

, 8:22

HPV Prevention


Since the introduction of the HPV vaccine, questions have been asked about its efficacy in preventing cancer linked with HPV. Concerns about the HPV vaccine safety profile have also been raised. This paper highlights the rapidly growing body of evidence including clinical trials and post-marketing surveillance illustrating both the safety of the HPV vaccine, through a detailed investigation of reported adverse events, and its efficacy in reducing both HPV infections rates and the resulting drop in cervical lesions, which have been demonstrated to be good predictors of cervical cancer risk.

KeywordsHuman papillomavirus HPV Safety Cervical cancer Cancer prevention Adverse events Clinical trials AbbreviationsHPVHuman papillomavirus

CINCervical intraepithelial neoplasia

MITTModified intention to treat

ITTIntention to treat

TVCTotal vaccine cohort

AISAdenocarcinoma in situ.

Electronic supplementary materialThe online version of this article doi:10.1186-1750-9378-8-22 contains supplementary material, which is available to authorized users.

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Autor: David Hawkes - Candice E Lea - Matthew J Berryman


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