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Infectious Agents and Cancer

, 8:31

First Online: 30 August 2013Received: 09 January 2013Accepted: 19 August 2013DOI: 10.1186-1750-9378-8-31

Cite this article as: Bernal-Silva, S., Granados, J., Gorodezky, C. et al. Infect Agents Cancer 2013 8: 31. doi:10.1186-1750-9378-8-31

Abstract

BackgroundPersistent infection with high-risk human papillomavirus HPV is a major risk factor for malignant lesions and cervical cancer. A widely studied element in the search for genetic factors influencing risk HPV infection diseases is allelic variation of the human leukocyte antigen HLA locus. The study was designed to search for HLA susceptibility alleles contributing to the persistence of HPV infection in Mexican women.

MethodsA total of 172 subjects were divided into three groups: 1 HPV–persistent patients; 2 HPV–cleared; and 3 HPV–reinfected patients. They were screened for HPV types using a polymerase chain reaction PCR. PCR-sequence specific oligonucleotide probes PCR-SSOP was used for HLA DRB1 and DQB 1 typing.

ResultsWe observed that HLA-DQB1*0501 allele might be associated with susceptibility of reinfection with HPV p = 0.01, OR = 4.9, CI 95% = 1.3 -18.7. Allele frequency of HLA-DRB1*14 was particularly reduced in patients with cancer when compared with the HPV–persistent group p = 0.04, suggesting that this allele is a possible protective factor for the development of cervical cancer OR = 2.98. HLA-DRB1*07 might be associated with viral clearance p = 0.04.

ConclusionsGenetic markers for HPV infection susceptibility are different in each population, in Mexicans several HLA-DQB1 alleles might be associated with an enhanced risk for viral persistence. In contrast, DRB1*14, seems to confer protection against cervical cancer.

KeywordsHPV HLA class II Susceptibility Persistent infection DRB1 AbbreviationsHPVHuman papillomavirus

CCCervical cancer

PCRPolymerase chain reaction

PCR-SSOPSequence specific oligonucleotide probes PCR

CMRCell mediated immune response

HLAHuman leukocyte antigen

HSILHigh squamous intraepithelial lesion

LSILLow squamous intraepithelial lesion

HR-HPVHigh-risk HPV types

LR-HPVLow-risk types

g.fGene frequency

OROdds ratios

CIConfidence interval.

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Autor: Sofía Bernal-Silva - Julio Granados - Clara Gorodezky - Carmen Aláez - Hilario Flores-Aguilar - Ricardo M Cerda-Flores -

Fuente: https://link.springer.com/







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