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Breast Cancer Research and Treatment

, Volume 141, Issue 2, pp 187–195

First Online: 29 August 2013Received: 22 July 2013Accepted: 17 August 2013DOI: 10.1007-s10549-013-2674-z

Cite this article as: Förnvik, D., Andersson, I., Dustler, M. et al. Breast Cancer Res Treat 2013 141: 187. doi:10.1007-s10549-013-2674-z


This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell CTC count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years range, 51–87 years. In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa range, 1.0–22.5 kPa and the average mean breast pressure 3.4 ± 1.6 kPa range, 1.5–7.1 kPa was statistically significant p < 0.001, confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm range, 9–30 mm. Four subjects 17 % were CTC positive before compression and two of these 8 % were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm range of the longest diameter, 5–12 μm. The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood.

KeywordsCirculating tumor cells Breast compression Breast cancer Mammography  Download fulltext PDF

Autor: Daniel Förnvik - Ingvar Andersson - Magnus Dustler - Roy Ehrnström - Lisa Rydén - Anders Tingberg - Sophia Zackrisson -


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