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Journal of Experimental and Clinical Cancer Research

, 32:87

First Online: 05 November 2013Received: 21 August 2013Accepted: 28 October 2013DOI: 10.1186-1756-9966-32-87

Cite this article as: Suriano, F., Santini, D., Perrone, G. et al. J Exp Clin Cancer Res 2013 32: 87. doi:10.1186-1756-9966-32-87

Abstract

BackgroundTo evaluate the prognostic role of TAMs in patients affected by non-muscle invasive bladder cancer NMIBC, undergone Trans Urethral Resection of Bladder TURB and Bacillus Calmette-Guerin BCG therapy.

MethodsData from 40 patients 36 men, 4 women, mean age 69 years 40-83 years, treated for NMIBC with TURB and BCG instillation were collected. Two different groups were considered: group with and group without bladder cancer recurrence. Correlations between immunofluorescence measured Mtot, M1 and M2 infiltration and clinicopathological parameters were evaluated using Spearman and Mann–Whitney methods. The recurrence-free survival rate was calculated using the Kaplan-Meier method.

ResultsCD68 positive cells Mtot were observed in all specimens tested. High Mtot, M1 and M2 infiltration was observed in patients with disease recurrence, even before endovescical BCG instillation. Significant value for M2 infiltration p = 0,042 was found calculating significativity between two group medians before BCG therapy. p = 0,072 and p = 0,180 were observed correlating median of Mtot and M1 between two groups of patients respectively. Values of p = 0,44, p = 0,23 and p = 0,64 from correlation between DFS and Mtot, M1 and M2 median in patients before endovescical BCG instillation, were calculated respectively. Comparing DFS and Mtot, M1 and M2 median in patients group after endovescical BCG instillation significant values were obtained p = 0,020; p = 0,02; and p = 0,029 respectively.

ConclusionsM2 tumor infiltration could be a prognostic value of recurrence in patients with NMIBC.

KeywordsBladder cancer Endovescical instillation Tumor-associated macrophages Macrophages polarization Prognosis Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-32-87 contains supplementary material, which is available to authorized users.

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Autor: Francesca Suriano - Daniele Santini - Giuseppe Perrone - Michela Amato - Bruno Vincenzi - Giuseppe Tonini - Andrea Onetti 

Fuente: https://link.springer.com/



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