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Gastroenterology Research and PracticeVolume 2012 2012, Article ID 846985, 8 pages

Review Article

Gastroenterology Department, Hospital Universitario de Canarias, 38320 La Laguna, Tenerife, Spain

Gastorenterology Department, Nuovo Regina Margherita Hospital, 00153 Rome, Italy

CPO Piemonte Department, AOU S. Giovanni Battista, 10123 Turin, Italy

Endoscopy Division, National Cancer Center Hospital, Tokyo 104-0045, Japan

Received 21 December 2011; Accepted 24 January 2012

Academic Editor: Haruhiro Inoue

Copyright © 2012 Enrique Quintero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although faecal and endoscopic tests appear to be effective in reducing colorectal cancer incidence and mortality, further technological and organizational advances are expected to improve the performance and acceptability of these tests. Several attempts to improve endoscopic technology have been made in order to improve the detection rate of neoplasia, especially in the proximal colon. Based on the latest evidence on the long-term efficacy of screening tests, new strategies including endoscopic and faecal modalities have also been proposed in order to improve participation and the diagnostic yield of programmatic screening. Overall, several factors in terms of both efficacy and costs of screening strategies, including the high cost of biological therapy for advanced colorectal cancer, are likely to affect the cost-effectiveness of CRC screening in the future.

Autor: Enrique Quintero, Cesare Hassan, Carlo Senore, and Yutaka Saito



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