Implementation of MR image-guided adaptive brachytherapy for cervix cancerReport as inadecuate

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optimization, brachytherapy, CT-MRI fusion, cervix cancer

Ren, Jiyun

Supervisor and department: Menon, Geetha Oncology Sloboda, Ron Oncology, Physics

Examining committee member and department: Fallone, Gino Oncology, Physics Robinson, Don Oncology, Physics Morsink, Sharon Physics

Department: Department of Physics


Date accepted: 2011-08-03T16:16:52Z

Graduation date: 2011-11

Degree: Master of Science

Degree level: Master's

Abstract: Currently, the Cross Cancer Institute uses CT imaging in conjunction with the traditional Manchester system, which prescribes dose to a defined point, for cervix cancer brachytherapy. To take advantage of MRI for enhanced definition of soft tissue including the cancerous tissue itself, this thesis focuses on a study of MR image-guided cervix brachytherapy. Firstly, the geometric distortions of an applicator in an MR image and the accuracy of CT-MRI registration were quantitatively evaluated with a custom-made phantom, which provides one measure of the MRI distortion and indicates a CT-MRI registration method for cervix brachytherapy. The remaining part of the thesis describes an optimization method - simulated annealing SA - for automatically determining the dwell time configuration based on a set of specified dose-volume constraints. Application to a computer simulation model showed that SA was effective when the model structure sizes and distances are in a normal range. The effects on the optimization of different initial dwell times and a different initial number of dwell positions were also investigated. In general, optimization conformed dose to the target and significantly reduced dose to surrounding normal tissue.

Language: English

DOI: doi:10.7939-R32S6P

Rights: License granted by Jiyun Ren on 2011-07-29T22:29:46Z GMT: Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.

Author: Ren, Jiyun



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