Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenograftsReport as inadecuate

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Journal of Experimental and Clinical Cancer Research

, 32:93

First Online: 19 November 2013Received: 21 October 2013Accepted: 14 November 2013DOI: 10.1186-1756-9966-32-93

Cite this article as: Gaustad, JV., Pozdniakova, V., Hompland, T. et al. J Exp Clin Cancer Res 2013 32: 93. doi:10.1186-1756-9966-32-93


BackgroundAntiangiogenic treatment may change the tumor microenvironment and hence influence the effect of conventional therapies. The potential of diffusion weighted magnetic resonance imaging DW-MRI and dynamic contrast enhanced MRI DCE-MRI in assessing microenvironmental effects of sunitinib treatment was investigated in this preclinical study.

MethodsSunitinib-treated and untreated A-07 tumors were subjected to DW-MRI and DCE-MRI, and parametric images of ADC and K were produced. Microvascular density, hypoxic fraction, and necrotic fraction were assessed from immunohistochemical preparations, and tumor interstitial fluid pressure IFP was assessed with probe measurement.

ResultsSunitinib-treated tumors showed reduced microvascular density, increased hypoxic fraction, increased necrotic fraction, increased ADC, and reduced K, but did not differ from untreated tumors in growth rate and IFP.

ConclusionsSunitinib treatment affected the tumor microenvironment without affecting tumor size. DW-MRI and DCE-MRI were sensitive to the sunitinib-induced changes in the tumor microenvironment.

KeywordsSunitinib Antiangiogenic treatment Hypoxia DW-MRI DCE-MRI Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-32-93 contains supplementary material, which is available to authorized users.

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Author: Jon-Vidar Gaustad - Viktoria Pozdniakova - Tord Hompland - Trude G Simonsen - Einar K Rofstad


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