Regulation of microRNAs by epigenetics and their interplay involved in cancerReport as inadecuate

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Journal of Experimental and Clinical Cancer Research

, 32:96

First Online: 22 November 2013Received: 21 October 2013Accepted: 14 November 2013DOI: 10.1186-1756-9966-32-96

Cite this article as: Liu, X., Chen, X., Yu, X. et al. J Exp Clin Cancer Res 2013 32: 96. doi:10.1186-1756-9966-32-96


Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modification on miRNA is not adequately understood. EZH2 and HDACs were recently identified as critical histone modifiers of deregulated miRNAs in cancer and can be recruited to a miRNA promoter by transcription factors such as MYC. Because miRNAs can modulate epigenetic architecture and can be regulated by epigenetic alteration, they could reasonably play an important role in mediating the crosstalk between epigenetic regulators. The complicated network between miRNAs and epigenetic machineries underlies the epigenetic–miRNA regulatory pathway, which is important in monitoring gene expression profiles. Regulation of miRNAs by inducing epigenetic changes reveals promising avenues for the design of innovative strategies in the fight against human cancer.

KeywordsmicroRNA Epigenetic DNA methylation Histone modification Cancer AbbreviationsDNMTsDNA methyltransferases

BCLB-cell lymphomas

HDACsHistone deacetylases

EZH2Enhancer of zeste homolog 2

YY-1Yin and yang 1

NF-κBNuclear factor κB


IκBαInhibitor of nuclear factor κB α

CLLChronic lymphocytic leukemia

MCLMantle cell lymphoma

ATLAdult T cell leukemia

API-5Apoptosis inhibitor-5

HCCHepatocellular carcinoma

TSATrichostatin A

AMLAcute myeloid leukemia

HATsHistone acetyltransferases

HMTsHistone methyltransferases

HDTsHistone demethylases

LSD1Lysine-specific demethylase 1


5-Aza-CdR5-aza-2′- deoxycytidine

MDSMyelodysplastic syndromes

SAHASuberoylanilide hydroxamic acid

CTCLCutaneous T-cell lymphoma




DZNep3-deazaneplanocin A.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-32-96 contains supplementary material, which is available to authorized users.

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Author: Xiaolan Liu - Xiaoyan Chen - Xinfang Yu - Yongguang Tao - Ann M Bode - Zigang Dong - Ya Cao


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