Kinetic analysis of 11Cbefloxatone in the human brain, a selective radioligand to image monoamine oxidase AReportar como inadecuado




Kinetic analysis of 11Cbefloxatone in the human brain, a selective radioligand to image monoamine oxidase A - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

EJNMMI Research

, 3:78

First Online: 25 November 2013Received: 13 September 2013Accepted: 21 October 2013DOI: 10.1186-2191-219X-3-78

Cite this article as: Zanotti-Fregonara, P., Leroy, C., Roumenov, D. et al. EJNMMI Res 2013 3: 78. doi:10.1186-2191-219X-3-78

Abstract

BackgroundCBefloxatone measures the density of the enzyme monoamine oxidase A MAO-A in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and psychiatric illnesses. This study sought to estimate the distribution volume VT values of Cbefloxatone in humans using an arterial input function.

MethodsSeven healthy volunteers were imaged with positron emission tomography PET after Cbefloxatone injection. Kinetic analysis was performed using an arterial input function in association with compartmental modeling and with the Logan plot, multilinear analysis MA1, and standard spectral analysis SA at both the regional and voxel level. Arterialized venous samples were drawn as an alternative and less invasive input function.

ResultsAn unconstrained two-compartment model reliably quantified VT values in large brain regions. A constrained model did not significantly improve VT identifiability. Similar VT results were obtained using SA; however, the Logan plot and MA1 slightly underestimated VT values about -10%. At the voxel level, SA showed a very small bias +2% compared to compartmental modeling, Logan severely underestimated VT values, and voxel-wise images obtained with MA1 were too noisy to be reliably quantified. Arterialized venous blood samples did not provide a satisfactory alternative input function as the Logan-VT regional values were not comparable to those obtained with arterial sampling in all subjects.

ConclusionsBinding of Cbefloxatone to MAO-A can be quantified using an arterial input function and a two-compartment model or, in parametric images, with SA.

KeywordsCBefloxatone Monoamine oxidase A PET Spectral analysis Electronic supplementary materialThe online version of this article doi:10.1186-2191-219X-3-78 contains supplementary material, which is available to authorized users.

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Autor: Paolo Zanotti-Fregonara - Claire Leroy - Dimitri Roumenov - Christian Trichard - Jean-Luc Martinot - Michel Bottlaender

Fuente: https://link.springer.com/



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