Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in RatsReport as inadecuate




Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats - Download this document for free, or read online. Document in PDF available to download.

Mediators of InflammationVolume 2013 2013, Article ID 928137, 5 pages

Research ArticleDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42075 Konya, Turkey

Received 21 August 2013; Revised 11 October 2013; Accepted 31 October 2013

Academic Editor: Dariusz J. Skarzyński

Copyright © 2013 Ayse Er. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg

day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg

on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg

day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg

on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha TNF-α and interleukin IL-10 levels were measured by ELISA. Azithromycin prevented LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.





Author: Ayse Er

Source: https://www.hindawi.com/



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