18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine gliomaReport as inadecuate

18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma - Download this document for free, or read online. Document in PDF available to download.

EJNMMI Research

, 4:8

First Online: 28 January 2014Received: 20 September 2013Accepted: 14 January 2014DOI: 10.1186-2191-219X-4-8

Cite this article as: Jansen, M.H.A., Kloet, R.W., van Vuurden, D.G. et al. EJNMMI Res 2014 4: 8. doi:10.1186-2191-219X-4-8


BackgroundPositron emission tomography PET scanning with  Ffluorodeoxyglucose  F-FDG is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma DIPG is still unclear. For interpretation of  F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine  F-FDG standard uptake value ratios SUVr of the normal pons and to compare these to those of DIPG.

MethodsWe studied 36 subjects with a normal, non-affected pons aged 5 to 23 years and 6 patients with DIPG aged 4 to 17 years who underwent  F-FDG PET scanning. Magnetic resonance imaging MRI was co-registered to define the regions of interest. SUVr and SUVrmax for the pons-cerebellum SUVrp-c and the pons-occipital lobe SUVrp-o were calculated. Independent-samples t tests and Mann–Whitney U tests were used to compare the mean SUVr and Pearson’s test for correlations.

ResultsFor the normal pons, mean SUVrp-c and SUVrp-o were 0.65 ±0.054 and 0.51 ±0.056, respectively. No significant correlations were found between the SUVr of the normal pons and sex, age, nor pontine volume. A modest but statistically significant correlation was found between SUVr and post-injection time acquisition timing. For DIPG, mean SUVrp-c and SUVrp-o were 0.74 ±0.20 and 0.65 ±0.30, respectively, while mean SUVrpmax-c and SUVrpmax-o were 1.95 ±0.48 and 1.81 ±0.20, respectively.

ConclusionThe SUVr of the unaffected pons are strikingly constant between children, irrespective of sex and age, and can therefore be well used as a reference value for  F-FDG PET studies in DIPG.

KeywordsPositron emission tomography  Ffluorodeoxyglucose Pontine glioma Brain neoplasms Reference values Pons Electronic supplementary materialThe online version of this article doi:10.1186-2191-219X-4-8 contains supplementary material, which is available to authorized users.

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Author: Marc H A Jansen - Reina W Kloet - Dannis G van Vuurden - Sophie EM Veldhuijzen van Zanten - Birgit I Witte - Serge Go

Source: https://link.springer.com/

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